A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients: the RIFM expert panel.

نویسندگان

  • D Belsito
  • D Bickers
  • M Bruze
  • P Calow
  • H Greim
  • J M Hanifin
  • A E Rogers
  • J H Saurat
  • I G Sipes
  • H Tagami
چکیده

University of Missouri (Kansas City), c/o American Dermatology Associates, LLC, 6333 Long Avenue, Third Floor, Shawnee, KS 66216, USA Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Avenue, New York, NY 10032, USA Malmo University Hospital, Department of Occupational and Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden Roskilde University, Isafjordvej 66, Roskilde, DK 4000, Denmark e Technical University of Munich, Institute for Toxicology and Environmental Hygiene, Hohenbachernstrasse 15-17, Freising-Weihenstephan D-85354, Germany Oregon Health Sciences University, Department of Dermatology, Mail Code CH16D, 3303 SW Bond Avenue, Portland, Oregon 97239-4501, USA Boston University School of Medicine, Department of Pathology and Laboratory Medicine, 715 Albany Street, L-804, Boston, MA 02118-2526, USA Hospital Cantonal Universitaire, Clinique et Policlinique de Dermatologie, 24, Rue Micheli-du-Crest, Geneve 14 1211, Switzerland Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA 3-27-1 Kaigamori, Aoba-ku, Sendai 981-0942, Japan

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A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. RIFM Expert Panel.

The alkyl cyclic ketone (ACK) fragrance ingredients are a diverse group of structures with similar metabolic and toxicity profiles. ACK fragrance materials demonstrate low acute toxicity. Upon repeat dose testing, some adverse effects in biochemical and hematological parameters, and slightly increased liver and kidney weights were reported, primarily at high doses, resulting from adaptive effec...

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The safety assessment of fragrance materials.

Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimatio...

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RIFM fragrance ingredient safety assessment, Benzyl acetate, CAS Registry Number 140-11-4.

RIFM fragrance ingredient safety assessment, Benzyl acetate, CAS Registry Number 140-11-4 A.M. Api a, , D. Belsito , S. Bhatia , M. Bruze , P. Calow , M.L. Dagli , W. Dekant , A.D. Fryer , L. Kromidas , S. La Cava , J.F. Lalko , A. Lapczynski , D.C. Liebler , Y. Miyachi , V.T. Politano , G. Ritacco , D. Salvito , T.W. Schultz , J. Shen , I.G. Sipes , B. Wall , D.K. Wilcox a a Research Institute...

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RIFM fragrance ingredient safety assessment, allyl phenylacetate, CAS registry number 1797-74-6.

a Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA b Department of Dermatology, Member RIFM Expert Panel, Columbia University Medical Center, 161 Fort Washington Ave., New York, NY 10032, USA c Department of Occupational & Environmental Dermatology, Member RIFM Expert Panel, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo ...

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A toxicological and dermatological assessment of macrocyclic ketones when used as fragrance ingredients: the RIFM Expert Panel.

The macrocyclic ketone (MK) group of fragrance ingredients was evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.13% to 1.10%; systemic exposures vary from 0.0005 to 0.0441 mg/kg/day. The MKs had low acute toxicity and no significant repeat dose toxicity. Liver weight and blood biochemistry effects were reversible af...

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عنوان ژورنال:
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

دوره 48 Suppl 3  شماره 

صفحات  -

تاریخ انتشار 2010